small molecule eif4e inhibitors Search Results


small molecule eif4e inhibitors  (eFFECTOR Therapeutics)
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eFFECTOR Therapeutics small molecule eif4e inhibitors
Examples of reported inhibitors of m7GpppX cap binding to <t>eIF4E</t> and proposed acyclic nucleoside phosphonate prodrugs inspired by the anti-viral drugs, adefovir and tenofovir dipivoxil.
Small Molecule Eif4e Inhibitors, supplied by eFFECTOR Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Examples of reported inhibitors of m7GpppX cap binding to eIF4E and proposed acyclic nucleoside phosphonate prodrugs inspired by the anti-viral drugs, adefovir and tenofovir dipivoxil.

Journal: Journal of medicinal chemistry

Article Title: Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer

doi: 10.1021/acs.jmedchem.3c00917

Figure Lengend Snippet: Examples of reported inhibitors of m7GpppX cap binding to eIF4E and proposed acyclic nucleoside phosphonate prodrugs inspired by the anti-viral drugs, adefovir and tenofovir dipivoxil.

Article Snippet: These compounds, in addition to recently reported small molecule eIF4E inhibitors reported by eFFECTOR Therapeutics, 40 will provide important tools for validating eIF4E as an anti-cancer therapeutic target, as well as provide new insights into the role of cap-dependent translation in cancer and other relevant human diseases.

Techniques: Binding Assay

eIF4E bound to 7n. The eIF4E protein backbone is shown as a gray ribbon with residues that interact with 7n shown as sticks. 7n is shown as sticks with cyan carbons. Nitrogen atoms are colored blue, oxygens in red and phosphorus in orange. Dashed lines represent hydrogen bonds (PDB: 8SX4).

Journal: Journal of medicinal chemistry

Article Title: Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer

doi: 10.1021/acs.jmedchem.3c00917

Figure Lengend Snippet: eIF4E bound to 7n. The eIF4E protein backbone is shown as a gray ribbon with residues that interact with 7n shown as sticks. 7n is shown as sticks with cyan carbons. Nitrogen atoms are colored blue, oxygens in red and phosphorus in orange. Dashed lines represent hydrogen bonds (PDB: 8SX4).

Article Snippet: These compounds, in addition to recently reported small molecule eIF4E inhibitors reported by eFFECTOR Therapeutics, 40 will provide important tools for validating eIF4E as an anti-cancer therapeutic target, as well as provide new insights into the role of cap-dependent translation in cancer and other relevant human diseases.

Techniques:

Activation of eIF4E and cap-dependent translation.

Journal: Journal of medicinal chemistry

Article Title: Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer

doi: 10.1021/acs.jmedchem.3c00917

Figure Lengend Snippet: Activation of eIF4E and cap-dependent translation.

Article Snippet: These compounds, in addition to recently reported small molecule eIF4E inhibitors reported by eFFECTOR Therapeutics, 40 will provide important tools for validating eIF4E as an anti-cancer therapeutic target, as well as provide new insights into the role of cap-dependent translation in cancer and other relevant human diseases.

Techniques: Activation Assay